Because of copyright issues, countless books between around the 1930s until about 2000 were never digitized.
After around 2000 books started coming out in digital format, so at least there are digital copies of many of those, even if they are still under copyright.
I dunno, that "at least" worries me, digital actually more easier to be lost if it is under copyright, they just got deleted if they can not produce enough money. Physical may have higher chance to survive.
"Am I the only one that is not worried at all about the camera and super concerned about microphones ? The camera may see me staring into the screen, woo hoo. The microphones will hear everything I discuss, incl. confidential information."
All phones are suspect. We should go back to only carrying pagers.
> Note he doesn't state whether the difference was positive or negative.
But if taken (as it usually is) as a metaphor of life's choices, in this case his life choices made him Robert Frost, the famous, incredibly successful poet -- so it's implied that in his case taking road less traveled by was positive.
Now, if the subject of the poem was some anonymous nobody, then maybe the poem would be more ambiguous.
> What I do is take several diverse short video segments, like 100, concatenate them into 4 segments (example 23+24+26+27 since they have diverse lengths) and then xstack them into a 2-by-2 mosaic video.
Just out of curiosity.. what use do you have for a 2-by-2 mosaic video?
'Inmiced' lol! Thanks for keeping the titles accurate, so important especially with cancer research results. Happy holidays and I really enjoyed reading the quote on your profile https://news.ycombinator.com/user?id=dang
idk why I see so many comments like this on the medical threads of HN lately. Laboratory mice are close enough to us to do testing on and have provided reliable results throughout their use. A basic Wikipedia search shows references for all of those claims and more: https://en.wikipedia.org/wiki/Laboratory_mouse
That's because mouse models suck for many diseases. Cancer very much included, for two reasons:
1. Mice _love_ to get cancer naturally. If you have 100 mice, it's quite likely that around 20 of them will die within one year of cancer. This makes it difficult to extract useful signals. BTW, that's why if you see a study that a "chemical X results in cancer in mice", you should take that with a grain of salt.
2. Mice are small, so tumors are necessarily small too, with several orders of magnitude fewer cells than typical human tumors. So many drugs can just cure mice of cancer entirely, by killing cancerous cells too quickly to allow them to evolve resistance.
> If you have 100 mice, it's quite likely that around 20 of them will die within one year of cancer.
If you have 100 people, about 40 of them will be diagnosed with cancer over their lifetime (39/100 females and 41/100 males). Note "diagnosed with" is very different from "die" and "over lifetime" is not the same as "within one year", but the probability of people getting cancer naturally is high as well.
Sure. But in general, cancer risk should scale with the number of cell divisions, which is fairly low for mice. And other small, short-lived mammals like weasels are not as susceptible to cancer. Naked mole rats (also rodents!) are downright cancer-proof.
This all means that mice don't have a good natural cancer-suppression machinery, and this in turn makes them somewhat awkward to use to discover new treatments.
I'm not sure it follows that high incidences of cancer means that it's unhelpful to use them for research to understand the mechanisms of cancer. And I'm not sure that either of your observations one or two are pertinent in this case as it applies to the on/off protein switch, as it is not about guaging the statistical frequency of cancers or about killing cancer cells.
It’s a common trope in the field that we’ve already cured cancer in mice. They are similar enough to be a useful model for study. However, they are still quite different to the point where you never quite know how treatments will react… especially in cancer.
The biggest issue is that the mice we use for research typically have no or a highly depleted immune system. One of the biggest breakthroughs in the cancer field (IMO) is the development of humanized mice. These are mice that have had their immune system genes replaced with the human versions of these genes.
This is incredibly important for work like this where you’re studying cancer cell-immune cell interactions.
After around 2000 books started coming out in digital format, so at least there are digital copies of many of those, even if they are still under copyright.